Costochondritis is one of the most common musculoskeletal causes of anterior chest pain - reproducible tenderness at multiple costochondral junctions (typically 2nd-5th) without visible swelling. It predominantly affects women over 40. Tietze syndrome is much less common and is distinguished by a single visibly swollen costochondral junction (usually 2nd or 3rd) in younger adults. Both are diagnoses of exclusion - cardiac, pulmonary, and other serious causes must be ruled out first. Both are usually self-limiting and managed conservatively in primary care.
The anterior chest wall is formed by the sternum, costal cartilages, and ribs. Costochondral junctions are primary cartilaginous joints with no cavity. Costosternal joints 2nd-7th are synovial and can develop synovitis. The manubriosternal joint sits at the 2nd costal cartilage level.
Costochondritis is reproducible tenderness at multiple costochondral or costosternal junctions without visible swelling. Mechanisms include repetitive loading, prolonged coughing after URTI, and postural stress.
Tietze syndrome is localised painful firm swelling at a single upper costochondral junction (usually 2nd or 3rd) in younger adults. Considered inflammatory, often preceded by URTI or strain.
Major risk factors for costochondritis: female sex, age over 40, repetitive upper-body activity, prolonged cough, postural stress.
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